The evidence.
Every active ingredient in the VEDASCO® collection is sourced to the extract grade used in the RCT that established its mechanism. We cite the study, name the extract, and specify the standardisation. No guesswork. No approximation.
−27.9%
Reduction in perceived stress score (PSS-14) vs placebo at 28 days
Olsson EMG, von Schéele B, Panossian AG (2009). Planta Medica
n=60 · 28 days · Stressed adults with fatigue
View study ↗≈fluoxetine
Saffron 30mg equivalent to fluoxetine 20mg for mild-moderate depression
Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S (2006). Phytomedicine
n=40 · 6 weeks · Adults with mild-to-moderate depression
View study ↗+36%
Improvement in sperm progressive motility vs placebo at 6 months
Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, Ricciardo-Lamonica G, Boscaro M, Mazzanti L, Lenzi A (2009). Fertility and Sterility
n=60 · 6 months · Infertile men with idiopathic asthenozoospermia
View study ↗Sig.
Significant improvement in sleep quality across 16 RCTs (meta-analysis)
Bent S, Padula A, Moore D, Patterson M, Mehling W (2006). American Journal of Medicine
n=16 RCTs · Multiple studies · Adults with sleep disorders
View study ↗+20%
Improvement in mental performance score vs placebo during night shifts
Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H (2000). Phytomedicine
n=56 · 14 nights · Physicians during night duty
View study ↗−PSQI
Significant improvement in sleep quality score (PSQI) and stress vs placebo
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H (2019). Nutrients
n=30 · 4 weeks · Healthy adults
View study ↗52%
Patients reporting PMS symptom improvement vs 24% placebo (3 menstrual cycles)
Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D (2003). Phytomedicine
n=178 · 3 cycles · Women with PMS/PMDD
View study ↗+IIEF
Significant improvement in erectile function score (IIEF) vs placebo
Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E (2008). British Journal of Clinical Pharmacology
n=119 · 8 weeks · Men with erectile dysfunction
View study ↗What we excluded and why
On Ashwagandha.
Ashwagandha (Withania somnifera) has a strong body of clinical evidence — particularly for cortisol reduction and stress. We acknowledge this. It appears in several major adaptogen meta-analyses.
It is classified as a Novel Food in the EU under Regulation (EU) 2015/2283. Placing it in a supplement sold across EU member states would create regulatory exposure for customers at national level — particularly in France and Portugal.
Our EU formulations use Rhodiola rosea (EMA HMPC Traditional Use monograph), Vidarikand (Pueraria tuberosa), and Panax ginseng (EMA HMPC monograph) — each of which has an established regulatory status and comparable adaptogenic evidence base.